The research enterprise is highly dependent on collaboration. Initiative development and institutionalization requires collaboration among a wide range of stakeholders, including scientists, program directors, grants-making organizations, university research administrators, and Congress. Developing and distributing program descriptions, cultivating research proposals, and all of the other steps in solicitation, selection, and grants management require collaboration. For many, significant participation in the enterprise will increasingly be possible only through virtual collaboration. While more research and better tools are clearly needed, conference calls, teleconferences, and virtual workspaces already provide some opportunity to extend participation. Thoughtful, evaluative use of these basic collaboration technologies will not only inform their further development, it can also deliver value to the enterprise today.