The research enterprise is continuously cultivating the next generation of questions that will advance science. This entails decisions about which research topics to invest in today balanced with decisions about what initiatives to create for tomorrow. This requires that information and ideas flow freely within the enterprise and that processes exist to ensure their full consideration. Research on this topic could generate and test benchmarks for evaluating existing approaches to generating initiatives. Such research might include a comparative analysis of current practices for identifying topics, criteria for judging the success of the process, or an evaluation of the implementation of initiatives originating from different sources. It might also address the potential of new Web technologies for collaborating on the definition and selection of new initiatives.