While each theme above suggests important research questions of its own, a different set of questions emerges from a more holistic look at the research enterprise. These questions highlight the interdependencies among the themes. They might be thought of as integrative goals that span the thematic areas and move us toward practical applications. These include research that will generate and test:

• new ways to identify and define the substantive goals of research initiatives
• new models of the grants-supported research process that make different assumptions about roles, relationships, and responsibilities of the various players
• alternative strategies and new technologies to support the review and selection of research proposals
• incentives for collaboration across disciplines, roles, and organizations
• new technologies for multimedia proposal development, submission, and management
• information-centric processes as tools for an enterprisewide orientation